Endocrine Abstracts

Outpatient theranostics began 30 years ago in Western Australia with world-first phase 1/11 clinical trials of Samarium-153-EDTMP for pain palliation of skeletal metastases prospective individualised dosimetry in each patient, based upon a calculated maximum radiation absorbed dose of 2Gy to haemopoietic marrow was performed by quantitative whole-body gamma imaging, to prescribe the safe effective administered therapeutic activity, which was then given on the same day as an ou...

Introduction: The GH/IGF-I axis is implicated in colorectal cancer development. We have previously shown regional variations of the GH/IGF-I axis, and other tumour associated genes between the rectum (RS) and caecum (C). Whether variations in the GH/IGF-I axis align with differing expression patterns is unknown.Aim: To determine the association between colonic expression of the GH/IGF-I axis and that of tumour associated genes by region.<p class="abs...

Context: To diagnose and monitor GH-related disorders, serum IGF-I is a cornerstone, but Indian ethnicity based data, following consensus criteria for establishment of normative data are not available.Objectives: To generate normative IGF-I data for chronological age, bone age (BA) [Greulich & Pyle] and Tanner stage for both genders.Setting and Participants: We conducted a cross-sectional epidemiological study for children (age...

Obesity-associated inflammation is a major contributory factor in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the mechanisms underlying the progression of T2DM are yet to be fully elucidated. The adipokine, resistin, has recently been implicated as a pro-inflammatory cytokine in obesity-related T2DM. Therefore, the aim of this study was to characterise the role of resistin in the innate immune inflammatory pathway within isolated human abdominal subcutaneous ...

High levels of GH and low levels of IGF-I are found in the serum of type 1 DM. GH binds to its receptor (GHR) and leads to a series of signal transduction reactions, involving phosphorylation of intracellular proteins, including IGF-I and angiotensin II receptor type I (AT1R). It has been previously shown that in type I DM mice there is a decrease in liver GHR levels and circulating IGF-? in spite of increased circulating GH, suggesting a state of GH resistance, although its e...

Retinoic-acid-inducible gene I (RIG-I) is a cytosolic receptor that sense RNA viruses, such as influenza, producing proinflammatory cytokines and type 1 interferons. In severe influenza infection, inappropriate immune response can allow influenza virus to proliferate, triggering hypercytokinemia that leads to tissue damage and potentially death of the host. Glucocorticoid hormones (GC) are clinically used to suppress hypercytokinemia. However, the use of GC is controversial du...

Introduction: In sheep, modest maternal nutrient restriction over the period of rapid placental growth restricts placentome growth. Maternal plasma IGF-I concentration is unaffected but effects on placental IGF-I receptor mRNA expression are not known.Methods: Twenty singleton-bearing ewes of similar body weight and parity were entered into the study. Ten ewes consumed 60% of their total energy requirements (i.e. nutrient restricted, NR) from 28 to 80 da...

Bariatric or metabolic surgery, such as Roux-en-Y gastric bypass and sleeve gastrectomy are becoming increasingly prevalent as these treatments are now recommended as treatment choices for obesity and type 2 diabetes. Post-bariatric hypoglycaemia (PBH), typically a post-prandial hyperinsulinaemic hypoglycaemia occurring 1-3 hr after ingestion of food, is now more commonly encountered in practice, presenting either to endocrine/metabolic outpatient clinics or during medical on-...

Background: Graves’ disease (GD) is a common autoimmune disease of unknown origin. Evidence of an association between autoimmune thyroid diseases and viral infections is, however, emerging. Human leukocyte antigen (HLA) class I presents both virally and self-derived antigens to circulating immune cells and plays a crucial role in the defense against viral infections. This study aimed to investigate the presence of enterovirus and HLA class I expression in a large GD coho...

Osteocytes make up >90% of bone cells, are embedded in mineralised matrix where they form a communication network. Osteocytes differentiate from osteoblasts, and are thought to be mechano-sensitive. They are very difficult to isolate leading to a dependence on cell lines for in vitro studies of osteocyte biology. There is thus a need to develop new methods to study these cells. Recent publications indicate that osteoblasts maintained in in vitro 3D collagen g...